The autoimmune disease has primary lesions are superficial pustules, which frequently rupture to form crusts with underlying erosions. In cats, lesions most frequently develop at or around the nasal planum and muzzle, pinnae (See Figure above, Classic pattern of feline pemphigus foliaceus with adherent crusts around the face, dorsal muzzle, periorbital region, and pinnae). Thickly crusted and erythematous, Excessive scaling of the footpads with crusts adherent to the footpad margins and nails. Pathophysiology ; The feline pemphigus foliaceus involves development of autoantibodies, which produce a loss of intercellular adhesion in the upper layers of the stratum corneum (acantholysis). This leads to vesicle and pustule formation. Genetics, drugs and other factors are known triggers for antikeratinocyte autoantibody induction. Diagnosis; Cytologic examination of pustule contents may provide a tentative diagnosis based on the presence of neutrophils and large rounded (acanthol...
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